Research achievements on proteoglycans

We have been conducting numerous studies on proteoglycans for nearly 20 years. Here we report on our achievements.

2021

Skin-moisturizing Effect of an Oral Supplement Containing Salmon Nasal Cartilage Proteoglycan—A Randomized, Double-blind, Parallel-group, Placebo-controlled Study―
　Jpn Pharmacol Ther Vol. 49, no. 3, 449 - 458 (2021)

2020

Improvement effect of proteoglycans on joint cartilage
　FOOD STYLE 21 2020, 7, P.51-54
　

Exogenous Application of Proteoglycan to the Cell Surface Microenvironment Facilitates to Chondrogenic Dierentiation and Maintenance
　Int. J. Mol. Sci. 2020, 21, 7744　


Role of Proteoglycans in the Process of Angiogenesis
　The 93rd Annual Meeting of the Japanese Biochemical Society　


Proteoglycans derived from salmon nasal cartilage create a microenvironment for stem cells
　The 140th Annual Meeting of The Pharmaceutical Society of Japan　
　

Oral Administration of Salmon Cartilage Proteoglycan Attenuates Osteoarthritis in a Monosodium Iodoacetate-Induced Rat Model
　Natural Product Communications. 2020.15(12).1–6 (Vietnam)　


SUBCHRONIC TOXICITY OF PROTEOGLYCAN F IN RATS
　JMR 127 E6 (3) 2020 (Vietnam)　

2019

Effects of salmon nasal cartilage proteoglycan on active glucose transport and water absorption in the small intestine
　Proteoglycans 2019 Conference 　


Attenuation of obesity-induced inflammation in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent
　Proteoglycans 2019 Conference 　


Structural analysis of the carbohydrate-protein linkage region of chondroitin sulfate proteoglycan derived from salmon nasal cartilage
　Proteoglycans 2019 Conference 　


Salmon nasal cartilage proteoglycan prevents cartilage degeneration in osteoarthritis of STR/ort mice
　Proteoglycans 2019 Conference 　


Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain induced respiratory inflammation
　Proteoglycans 2019 Conference 　


Alteration of intestinal microbiota in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent
　Proteoglycans 2019 Conference 　


Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice
　Proteoglycans 2019 Conference 　


Salmon cartilage proteoglycan promotes the healing process of Staphylococcus aureus-infected wound
　Proteoglycans 2019 Conference 　


Proteoglycan functions in the regulation of cell proliferation and endochondral ossification in cartilage
　Proteoglycans 2019 Conference 　


Proteoglycan contributes to stem cell environment in the cultured neural progenitors
　Proteoglycans 2019 Conference 　


Effect of proteoglycan on the total improvement of joint cartilage matrix
　Precision Medicine 31(1040)- Vol.2 No.11, 2019


The advantaged assessment for joint cartilage and the improvement effect of proteoglycan
　BIO Clinica 34(8), 99-104, 2019


Alleviation of Papain-induced Airway Inflammation by Oral Salmon Nasal Cartilage Proteoglycan
　73th Annual Meeting of Japan Society of Nutrition and Food Science

2018

Evaluation of the Efficacy and Safety of Long—term Intake of a Dietary Supplement Containing Salmon Nasal Cartilage—derived Proteoglycan on Subjects with Subjective Knee Symptoms ―An Open Study―
　Jpn Pharmacol Ther Volume 46, Issue 10, 1693 - 1706 (2018)　

Arthroprotective effects of salmon nasal cartilage-derived proteoglycan
　Functional Food Research 14：36-43，2018


Safety Evaluation of a Food Containing Salmon Nasal Cartilage—derived Proteoglycan （Proteoglycan F）―A Single—dose Toxicity Study in Rats―
　Jpn Pharmacol Ther Volume 46, Issue 4, 523 - 527 (2018)　


Effect of Proteoglycans on Locomotive Syndrome
　FOOD STYLE 21 2018, 3, P.69-71


Arthroprotective effects of salmon nasal cartilage-derived proteoglycan
　The 14th Functional Food Society

2017

The Safety Evaluation of Excessive Consumption of Salmon Nasal Cartilage-derived Proteoglycan
　Pharmacometrics Vol.93 No.1/2　

Effects of salmon nasal cartilage proteoglycan as a useful therapeutic agent, cosmetics and functional food
　The 19th Asian Regional Association for Home Economics　

Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double‑blind placebo‑controlled clinical study
　EXPERIMENTAL AND THERAPEUTIC MEDICINE 14: 115-126, 2017

2016

Proteoglycans, a newly discovered functional ingredient
　Japan Anti-Aging Foundation 1st Academic Forum　

2015

Ingestion of salmon nasal cartilage-derived proteoglycan improved skin condition: a randomized, double blind, control study.
　Immunology, Endocrine and Metabolic Agents　


Effects of Salmon Nasal Cartilage Proteoglycan on Plasma Glucose Concentration and Active Glucose Transport in the Small Intestine.
　J Nutr Sci Vitaminol (Tokyo). 2015;61(6):502-5　


Safety Evaluation of Highly Purified Proteoglycan Industrially Extracted from Salmon Nasal Cartilage.
　Pharmacometrics 89(1/2): 15-22, 2015


Structural analysis of chondroitin sulfate proteoglycans from salmon nasal cartilage
　The 135th Annual Meeting of The Pharmaceutical Society of Japan

2013

Absorption of proteoglycan via clathrin-mediated endocytosis in the small intestine of rats.
　Annual Meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry 2013

Proteoglycan; Its Use and Absorption in the Intestine.
　BIT's 4th World Gene Convention 2013


Absorption of proteoglycan via clathrin-mediated endocytosis in the small intestine of rats.
　Biosci Biotechnol Biochem. 77(3):654-656

2011

Improvement of knee joint pain by oral intake of proteoglycans and its effect on chondrocyte progenitor cell line ATDC5
　The 13th International Congress of Integrative Medicine


Improvement of knee joint pain by oral intake of salmon nasal cartilage-derived proteoglycan in humans and its effect on chondrocyte progenitor cell line ATDC5
　Annual Meeting of Japan Society of Nutrition and Food Science


A Novel Skin Moisturizer: Development of Proteoglycan for its Excellent Moisturizing Effect.
　10th ASCS Conference Seoul Korea, Abstracts, 128-129, full paper 1-5 (2011)


Influence on improvement of asteoarthritis by oral intake of proteoglycan extracted from salmon nasal cartilage.
　The International Society for Nutraceuticals and Functional Foods

2010

Effects of salmon nasal cartilage-derived proteoglycan on cell proliferation and chondrogenic differentiation in the chondrogenic progenitor cell line ATDC5.
　The 28th Annual Meeting of The Japanese Society for Bone and Mineral Research


Effect of oral ingestion of salmon nasal cartilage-derived proteoglycans on cultured skin cells and human skin
　The 57th Annual Meeting of Japanese Society For Food Science And Technology

2009

Benefits of proteoglycans from salmon nasal cartilage
　The 3rd Symposium on Pharmaceutical Food Science 11.12-13.