The warrior of dermal matrix against sagging

Loss of hyaluronic acid (HA) cause wrinkle and sagging

HA is an important component of the extracellular matrix (ECM). Many people will imagine the following properties of HA: moisture, softness and viscosity. But how about the relationship with the strength of the ECM structure? Past reports show that a low amount of HA is correlated with large sagging and deep wrinkle. Moreover, the amount of HA decreases with aging.

HYBID, the novel mechanism of dermal HA degradation

In the epidermis, HA was known to be cleaved by HYAL1/2. In the dermis, on the other hand, HYBID (HYaluronan-Binding protein Involved in hyaluronan Depolymerization) is recently identified as a major HA cleavage enzyme. Natural aging and extrinsic stimuli like UV and histamine promote the expression of HYBID. This is a major cause of dermal sagging and wrinkles. We tried to suppress HYBID by natural ingredient and found Artemisia capillaris flower Extract.

New active ingredient identified and named by us!

Published Paper - Scientific Reports

HyaluGuard, the warrior of dermal matrix against sagging

# Inhibition of expression of HYBID
# Reduction of skin sagging
# Reduction of skin wrinkle
# Increase in moisture content

HyaluGuard uses Japanese Artemisia capillaris.
HyaluGuard is manufactured using 1,3-Butylene Glycol which is obtained from Sugarcane.

Branding page / HyaluGuard

Product information / HyaluGuard