The uneven skin tone refers to the heterogenous distribution of not only a single-colored molecule but also a combination of various colored complexes such as brown, black, and gray ones, each of which can develop the individual skin color tone. Whereas the presence of Advanced Glycation End-products (AGEs) by themselves are responsible for the development of brown skin tone, they may mediate signal transduction by binding to their receptors, RAGE (receptors for AGEs), for the development of black tone and gray tone through producing melanin by melanocytes and suppressing differentiation of keratinocytes, respectively. So, the inhibition of AGEs production and their subsequent signaling pathways might hold the key to comprehensively achieving an evenness of all colored skin tones.

ICHIMARU PHARCOS proposes three natural cosmetic ingredients that resolve uneven skin tone.

　

PeoGlow improves the skin tone unevenness by inhibiting the binding of AGEs to RAGE, which can be the origin of brown, black and grey dark tone. PeoGlow provides a fundamental approach to improving overall uneven skin tone and achieving radiant, glowing, beautiful skin.

# Reduction of uneven skin tone
# Reduction of AGEs
# Stop of AGEs-RAGE signal
# Reduction of age spots

Featured Products / PeoGlow

　

Absorage is an anti-glycation ingredient that prevents protein glycation and prevents skin transparency loss and skin aging (wrinkles, reduced flexibility).

# Prevention of skin browning
# Reduction of AGEs
# Reduction of wrinkles

Product information page / Absorage

　

Lipofuscin, that accumulates in cells with age, reduces skin transparency by blocking light transmission and causes skin dullness. We focused on both proteasome and autophagy, the intracellular purification systems, and developed JuniperBright which increased their activities and suppressed accumulation of lipofuscin in human epidermal keratinocytes.

# Reduction of lipofuscin accumulation (through activation of proteasome and autophagy)
# Skin brightening
# Increase of internal reflected light
# Reduction of skin age spots

Branding page / JuniperBright

Please contact us for samples and further information.