Focus on “R-spondin 1”
which activates
the outer root sheath,
the foundation of hair follicles

Natural Cosmetic Ingredient BURGEON-UP

<Nasturtium Officinale Leaf/
Stem Extract>

  • in-cosmetics asia
  • BSB Innovation Award
  • HAIR GROWTH
  • SCALP CARE

Works at a cellular level for real results:
R-spondin1

R-spondin 1 is a protein involved in the regeneration of organs and tissue is currently increasing attention in the field of regenerative medicine. In the field of hair science, R-spondin 1 activates the foundation of hair follicles, known as the outer root sheath, which is important in making thick hairs that do not come out easily. This led to the development of BURGEON-UP which is the hair growth material applied for the first time.
As BURGEON-UP also suppresses the mechanism of action of male hormones, it activates follicles while also preventing hair loss. In addition to male hair loss, BURGEON-UP is expected to work on female hair loss.

Special production

BURGEON-UP utilizes freshly procured Nasturtium officinale (watercress) grown in Japan from partnering farms to retain the product's high quality. This watercress is cultivated on fertile land with pure water and with the care of its growers.

Benefits

BURGEON-UP functionality

01

Promoting the secretion of R-spondin 1

02

Suppressing the secretion of hair loss factor DKK 1

03

Human hair follicle elongation

04

Hair growth in clinical trials

Awards

in-cosmetics asia

in-cosmetics Asia 2019 finalist in the “Best Ingredient” Innovation award actives category

BSB Innovation Award

BSB Innovation Award 2020 second prize in the "scalp, hair, moisture, tan"  Natural Products / Raw materials category

Features

IECIC2015

Japanese Quasi-Drug

Natural solvent

Paraben free

Not tested on animals

Mechanism of BURGEON-UP

Suppresses the action mechanism of male hormones (protecting the Anagen) and
activates hair follicles (stimulating the Anagen).

In hair tissues, the tissue regeneration-related protein R-spondin 1 binds with the receptors (LGR5) in the outer root sheath, which is the foundation of hair follicles ;activates cells; and stimulates hair growth.
Additionally, R-spondin 1 suppresses the production of the hair loss factor DKK 1, which works in the mechanism of action of male hormones.
BURGEON-UP is expected to have a“double punch” benefit by promoting the secretion of R-spondin 1 from dermal papilla cells to stimulate hair growth while also preventing hair loss caused by male hormones.

Effects

The following test results demonstrate the usefulness of the product.

IN VITRO
Promotion of R-spondin 1 secretion
Found from the addition of BURGEON-UP to human hair papilla cells and measurement of R-spondin1 on a culture supernatant
IN VITRO
Suppression of hair loss factor DKK1 secretion
Tested through the addition of BURGEON-UP and DHT to human hair papilla cells and measurement of DKK1 on a culture supernatant
IN VITRO
Suppression of hair loss factor IL-6 secretion
Discovered from the addition of BURGEON-UP and DHT to human hair papilla cells and measurement of IL-6 on a culture supernatant
EX VIVO
Human hair follicle elongation
Found from an organ culture of hair follicles taken from the scalp of a woman in her 30s and measurement of hair length
IN VIVO
Hair growth in
clinical trials
Tested through the application of 2% BURGEON-UP to the scalps of 40 men in India and observation of hair diameter, density, and number of strands in the growth period one month later

Contact us if you want to know more about the test results and how tests were conducted.

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Specifications

Name
BURGEON-UP
Description
Light yellow to yellow liquid, having slightly characteristic odor
INCI
Water, Alcohol, Nasturtium Offi cinale Leaf/Stem Extract
IECIC 2015 listing
水,乙醇,豆瓣菜(NASTURTIUM OFFICINALE) 叶/ 茎提取物
Recommended
blending amount
2%
Characteristics
Liquid, Water soluble, Without preservatives

Applications

The following test results demonstrate the usefulness of the product.

  • Hair growth
  • Anti-hair loss treatment
  • Anti-aging hair serum
  • Eyebrow growth serum
  • Eyelash growth serum
  • Active mascara

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Essays

Frequently asked questions

RSPO1 is used in the creation of organoids. It is also applied through eye drops in clinical trials for the reproduction of corneal endothelial cells.

The outer root sheath refers to the entire sheath around a hair follicle. The cells which make up the sheath are known as outer root sheath cells. The bulge is a section of the outer root sheath. Stem cells and their descendants, progenitor cells (cells endowed with stem cell qualities and ample multiplicative ability), exist within outer root sheath cells.

With hair loss from diffuse alopecia, rare in females, there is no ability to enter into a growth period and dormancy periods become longer. RSPO1 is an active factor in bringing hair from a period of dormancy to one of growth, and so an increase in it induces a growth period in hair follicles. Thus, it is believed RSPO1 can be used as a countermeasure against the symptoms of diffuse alopecia.
Furthermore, DKK1 and similar agents are effective in suppressing hair loss factors giving rise to male pattern baldness in females. BURGEON-UP is effective in both inducing the growth period and suppressing hair loss, which makes it conceivable that it would be effective in counteracting female hair loss and thinning.

Eyelashes have no hormones, so it cannot prevent hair loss there, but it shows promise in terms of hair growth.

We recommend ingredients active with hair papilla cells (e.g. Biocellact CHAMOMILLA BD).

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About us

Who we are

After the establishment in 1959, ICHIMARU PHARCOS has become a global leader in Research and Development of natural active ingredients for the cosmetic industry. Locating in Gifu prefecture, Japan, the company has gained reputation and trust from world leading cosmetic brands including small scale cosmetic manufacturers for efficient support and service. ICHIMARU PHARCOS provides more than 1,000 ingredients from natural resources to cosmetics and food industries all over the world.

What we do

ICHIMARU PHARCOS focuses primarily on the research and development of natural ingredients. Approximately 30 percent employees are research and development scientists. By cooperating with reputed universities and research institutes, we have established a secured research and development base. Taking into consideration the potential needs of customers regarding beauty and health, ICHIMARU PHARCOS develops new ingredients for cosmetics and health foods as well as creates new trends.

Areas of expertise

  • Active
    Ingredients

  • Sustainability

  • Skin Care

  • Scalp & Hair Care

  • Natural
    Ingredients

Contact

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