Proteoglycan的研究成果

近20年来，我们一直在进行大量关于蛋白多糖的研究。这里我们报告我们的成就。

2021

Skin-moisturizing Effect of an Oral Supplement Containing Salmon Nasal Cartilage Proteoglycan—A Randomized, Double-blind, Parallel-group, Placebo-controlled Study―
（含有鲑鱼鼻软骨蛋白多糖的口服补充剂的皮肤保湿效果--随机、双盲、平行组、安慰剂对照研究。）
　Jpn Pharmacol Ther Vol. 49, no. 3, 449 - 458 (2021)

2020

Improvement effect of proteoglycans on joint cartilage
（蛋白多糖对关节软骨的改善作用）
　FOOD STYLE 21 2020, 7, P.51-54
　

Exogenous Application of Proteoglycan to the Cell Surface Microenvironment Facilitates to Chondrogenic Dierentiation and Maintenance
（蛋白多糖在细胞表面微环境中的外源性应用促进了软骨分化和维持）
　Int. J. Mol. Sci. 2020, 21, 7744　


Role of Proteoglycans in the Process of Angiogenesis
（蛋白多糖在血管生成过程中的作用）
　The 93rd Annual Meeting of the Japanese Biochemical Society　


Proteoglycans derived from salmon nasal cartilage create a microenvironment for stem cells
（来自鲑鱼鼻翼软骨的蛋白多糖为干细胞创造了一个微环境）
　The 140th Annual Meeting of The Pharmaceutical Society of Japan　
　

Oral Administration of Salmon Cartilage Proteoglycan Attenuates Osteoarthritis in a Monosodium Iodoacetate-Induced Rat Model
（口服鲑鱼软骨蛋白多糖可减轻碘乙酸一钠诱导的大鼠模型的骨关节炎症状）
　Natural Product Communications. 2020.15(12).1–6 (Vietnam)　


SUBCHRONIC TOXICITY OF PROTEOGLYCAN F IN RATS
（蛋白多糖F对大鼠的亚慢性毒性）
　JMR 127 E6 (3) 2020 (Vietnam)　

2019

Effects of salmon nasal cartilage proteoglycan on active glucose transport and water absorption in the small intestine
（鲑鱼鼻软骨蛋白多糖对小肠主动葡萄糖运输和水分吸收的影响）
　Proteoglycans 2019 Conference 　


Attenuation of obesity-induced inflammation in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent
（口服鲑鱼软骨蛋白多糖（一种预防剂）对小鼠肥胖诱发的炎症的减弱）
　Proteoglycans 2019 Conference 　


Structural analysis of the carbohydrate-protein linkage region of chondroitin sulfate proteoglycan derived from salmon nasal cartilage
（来自鲑鱼鼻软骨的硫酸软骨素蛋白多糖的碳水化合物-蛋白质连接区的结构分析）
　Proteoglycans 2019 Conference 　


Salmon nasal cartilage proteoglycan prevents cartilage degeneration in osteoarthritis of STR/ort mice
（鲑鱼鼻腔软骨蛋白多糖可防止STR/ort小鼠骨关节炎的软骨变性）
　Proteoglycans 2019 Conference 　


Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain induced respiratory inflammation
（鲑鱼软骨蛋白多糖减弱木瓜蛋白酶诱导的呼吸道炎症小鼠模型中的过敏反应）
　Proteoglycans 2019 Conference 　


Alteration of intestinal microbiota in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent
（小鼠口服鲑鱼软骨蛋白多糖（一种预防剂）的肠道微生物群的改变）
　Proteoglycans 2019 Conference 　


Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice
（口服鲑鱼软骨蛋白多糖能延长小鼠异体移植的存活时间）
　Proteoglycans 2019 Conference 　


Salmon cartilage proteoglycan promotes the healing process of Staphylococcus aureus-infected wound
（鲑鱼软骨蛋白多糖促进金黄色葡萄球菌感染的伤口愈合过程）
　Proteoglycans 2019 Conference 　


Proteoglycan functions in the regulation of cell proliferation and endochondral ossification in cartilage
（蛋白多糖在调节软骨中的细胞增殖和软骨内骨化中的功能）
　Proteoglycans 2019 Conference 　


Proteoglycan contributes to stem cell environment in the cultured neural progenitors
（蛋白多糖有助于培养的神经祖细胞中的干细胞环境）
　Proteoglycans 2019 Conference 　


Effect of proteoglycan on the total improvement of joint cartilage matrix
（蛋白多糖对关节软骨基质全面改善的影响）
　Precision Medicine 31(1040)- Vol.2 No.11, 2019


The advantaged assessment for joint cartilage and the improvement effect of proteoglycan
（关节软骨的优势评估和蛋白多糖的改善效果）
　BIO Clinica 34(8), 99-104, 2019


Alleviation of Papain-induced Airway Inflammation by Oral Salmon Nasal Cartilage Proteoglycan
（口服鲑鱼鼻软骨蛋白多糖减轻木瓜蛋白酶诱导的气道炎症的作用）
　73th Annual Meeting of Japan Society of Nutrition and Food Science

2018

Evaluation of the Efficacy and Safety of Long—term Intake of a Dietary Supplement Containing Salmon Nasal Cartilage—derived Proteoglycan on Subjects with Subjective Knee Symptoms ―An Open Study―
（长期服用含有鲑鱼鼻腔软骨蛋白多糖的膳食补充剂对膝关节主观症状的疗效和安全性评估--一项公开研究）
　Jpn Pharmacol Ther Volume 46, Issue 10, 1693 - 1706 (2018)　


Arthroprotective effects of salmon nasal cartilage-derived proteoglycan
（鲑鱼鼻腔软骨衍生的蛋白多糖的关节保护作用）
　Functional Food Research 14：36-43，2018


Safety Evaluation of a Food Containing Salmon Nasal Cartilage—derived Proteoglycan （Proteoglycan F）―A Single—dose Toxicity Study in Rats―
（含有鲑鱼鼻软骨衍生蛋白多糖（Proteoglycan F）的食品的安全性评估--大鼠单剂量毒性研究）
　Jpn Pharmacol Ther Volume 46, Issue 4, 523 - 527 (2018)　


Effect of Proteoglycans on Locomotive Syndrome
（蛋白多糖对运动性综合征的影响）
　FOOD STYLE 21 2018, 3, P.69-71


Arthroprotective effects of salmon nasal cartilage-derived proteoglycan
（鲑鱼鼻腔软骨衍生的蛋白多糖的关节保护作用）
　The 14th Functional Food Society

2017

The Safety Evaluation of Excessive Consumption of Salmon Nasal Cartilage-derived Proteoglycan
（过量食用鲑鱼鼻软骨蛋白多糖的安全性评估）
　Pharmacometrics Vol.93 No.1/2　

Effects of salmon nasal cartilage proteoglycan as a useful therapeutic agent, cosmetics and functional food
（鲑鱼鼻腔软骨蛋白多糖作为有用的治疗剂、化妆品和功能食品的作用）
　The 19th Asian Regional Association for Home Economics　

Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double‑blind placebo‑controlled clinical study
（评价鲑鱼鼻腔蛋白多糖对膝关节不适者的软骨代谢生物标志物的影响。一项随机双盲安慰剂对照的临床研究）
　EXPERIMENTAL AND THERAPEUTIC MEDICINE 14: 115-126, 2017

2016

Proteoglycans, a newly discovered functional ingredient
（蛋白多糖，一种新发现的功能成分）
　Japan Anti-Aging Foundation 1st Academic Forum　

2015

Ingestion of salmon nasal cartilage-derived proteoglycan improved skin condition: a randomized, double blind, control study.
（摄取鲑鱼鼻软骨衍生的蛋白多糖改善皮肤状况：一项随机、双盲、对照研究。）
　Immunology, Endocrine and Metabolic Agents　


Effects of Salmon Nasal Cartilage Proteoglycan on Plasma Glucose Concentration and Active Glucose Transport in the Small Intestine.
（鲑鱼鼻软骨蛋白多糖对血浆葡萄糖浓度和小肠主动葡萄糖运输的影响。）
　J Nutr Sci Vitaminol (Tokyo). 2015;61(6):502-5　


Safety Evaluation of Highly Purified Proteoglycan Industrially Extracted from Salmon Nasal Cartilage.
（从鲑鱼鼻软骨中工业化提取的高纯度蛋白多糖的安全性评估。）
　Pharmacometrics 89(1/2): 15-22, 2015


Structural analysis of chondroitin sulfate proteoglycans from salmon nasal cartilage
（鲑鱼鼻腔软骨中硫酸软骨素蛋白多糖的结构分析）
　The 135th Annual Meeting of The Pharmaceutical Society of Japan

2013

Absorption of proteoglycan via clathrin-mediated endocytosis in the small intestine of rats.
（大鼠小肠中通过凝集素介导的内吞作用吸收蛋白多糖。）
　Annual Meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry 2013


Proteoglycan; Its Use and Absorption in the Intestine.
（Proteoglycan; 它在肠道中的使用和吸收。）
　BIT's 4th World Gene Convention 2013


Absorption of proteoglycan via clathrin-mediated endocytosis in the small intestine of rats.
（大鼠小肠中通过凝集素介导的内吞作用吸收蛋白多糖。）
　Biosci Biotechnol Biochem. 77(3):654-656

2011

Improvement of knee joint pain by oral intake of proteoglycans and its effect on chondrocyte progenitor cell line ATDC5
（口服蛋白多糖改善膝关节疼痛及其对软骨细胞祖细胞系ATDC5的影响）
　The 13th International Congress of Integrative Medicine


Improvement of knee joint pain by oral intake of salmon nasal cartilage-derived proteoglycan in humans and its effect on chondrocyte progenitor cell line ATDC5
（口服鲑鱼鼻软骨衍生的蛋白多糖对人类膝关节疼痛的改善及其对软骨细胞祖细胞系ATDC5的影响）
　Annual Meeting of Japan Society of Nutrition and Food Science


A Novel Skin Moisturizer: Development of Proteoglycan for its Excellent Moisturizing Effect.
（一种新型的皮肤保湿剂。蛋白质多糖的开发，使其具有优异的保湿效果。）
　10th ASCS Conference Seoul Korea, Abstracts, 128-129, full paper 1-5 (2011)


Influence on improvement of asteoarthritis by oral intake of proteoglycan extracted from salmon nasal cartilage.
（口服从鲑鱼鼻腔软骨中提取的蛋白多糖对改善哮喘性关节炎的影响。）
　The International Society for Nutraceuticals and Functional Foods

2010

Effects of salmon nasal cartilage-derived proteoglycan on cell proliferation and chondrogenic differentiation in the chondrogenic progenitor cell line ATDC5.
（鲑鱼鼻软骨衍生的蛋白多糖对软骨祖细胞系ATDC5的细胞增殖和软骨分化的影响。）
　The 28th Annual Meeting of The Japanese Society for Bone and Mineral Research


Effect of oral ingestion of salmon nasal cartilage-derived proteoglycans on cultured skin cells and human skin
（口服鲑鱼鼻软骨衍生的蛋白多糖对培养的皮肤细胞和人类皮肤的影响）
　The 57th Annual Meeting of Japanese Society For Food Science And Technology

2009

Benefits of proteoglycans from salmon nasal cartilage
（鲑鱼鼻软骨的蛋白多糖的好处）
　The 3rd Symposium on Pharmaceutical Food Science 11.12-13.