Ichimaru Pharcos launched two natural cosmetic ingredients;
SpringMint for anti-aging / BURGEON-UP for hair growth


Ichimaru Pharcos launched two natural cosmetic ingredients at in-Cosmetics Asia in Bangkok this year. One "SpringMint", first ingredient that inhibits extracellular ATP which is related to skin thinning in natural aging. Another is "BURGEON-UP", this is the first ingredient that uses regenerative medicine approach (R-spondin 1) to hair growth.

SpringMint

Skin thinning is a characteristic phenomenon in which the dermis becomes thinner as it ages. Although the detailed mechanism of thinning is still unknown, its gradual progression causes a decrease in elasticity and formation of wrinkles. Under environmental stress or due to aging, cells release ATP in the extracellular spaces (known as extracellular ATP : eATP) which, in turn, mediates signal transduction to the surrounding healthy cells and induces aging. This ultimately causes the skin thinner by degrading the main component of extracellular matrix, collagen.
"SpringMint" maintains the thickness of skin by inhibiting the release of eATP.

Proven efficacy

in vitro	in vivo
# Suppressing production of extracellular ATP from aging epidermal cells # Suppressing SASP* expression induced by extracellular ATP *SASP : Senescence-Associated Secretory Phenotype	# Increasing the thickness of dermis (suppress thinning) # Improving skin's elasticity

INCI
Butylene Glycol, Water, Mentha Piperita (Peppermint) Leaf Extract

Characteristics
Organic peppermint
100% natural ingredient
IECIC 2015

BURGEON-UP

BURGEON-UP is an epoch-making product focusing on R-spondin 1 (RSPO1) which has attracted attention in regenerative medicine. BURGEON-UP upregulates RSPO1 secretion from dermal papilla, and elongate the hair follicle by promoting transition from Telogen (resting phase) to Anagen (growth phase). In addition, RSPO1 extends each follicle's period in Anagen by inhibiting the damage of dihydrotestosterone - induced hair loss factor (DKK1).
For ex vivo test, BURGEON-UP was confirmed to increase the elongation of the woman hair follicle tissues.

Proven efficacy

in vitro	ex vivo	in vivo
# Promoting the secretion of R-spondin 1 # Suppressing the secretion of hair loss factor DKK 1	# Human hair follicle elongation	# Hair growth in clinical trials (Total hair number, hair growth rate and hair thickness)

INCI
Water, Alcohol, Nasturtium Officinale Leaf/Stem Extract

Characteristics
100% natural ingredient
Plant grown in Japan
IECIC 2015